Ohio State Buckeyes quarterback Will Howard and the No. 12 Buckeyes are 12.5-point favorites over the Northwestern Wildcats in their Week 11 matchup Saturday at noon ET on Fox.
Ohio State enters the game 6-3 overall and 2-1 against AP Top 25 opponents. Northwestern is also 6-3 but 0-2 against AP Top 25 teams.
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DraftKings odds list Ohio State at -470 on the money line, with Northwestern at +360. The Over/Under is set at 46.5 points. ESPN’s Football Power Index projects Ohio State to win by 15.1 points, giving the Buckeyes an 85% probability of victory.
Week 11 features several high-stakes matchups. No. 2 Georgia Bulldogs host No. 18 Missouri Tigers at 3:30 p.m. ET on ABC; Georgia is a 15.5-point favorite. No. 4 Indiana Hoosiers welcome No. 20 USC Trojans at 3:30 p.m. ET on CBS; Indiana is favored by 7.5 points. No. 7 Texas Longhorns visit No. 14 LSU Tigers at 7:30 p.m. ET on ABC; LSU is a 3.5-point favorite.
Other notable lines include No. 1 Miami Hurricanes favored by 13.5 over Duke Blue Devils, No. 5 Alabama Crimson Tide favored by 16.5 over Vanderbilt Commodores, and No. 11 Notre Dame Fighting Irish favored by 29.5 over Boston College Eagles.
The College Football Playoff rankings will be updated on Monday, November 10 — one day after this weekend’s games conclude. All odds and projections are subject to change and are sourced from DraftKings and ESPN’s FPI as of Monday, November 9, 2026.
More: NCAAF · Ohio State Buckeyes · Georgia Bulldogs · Notre Dame Fighting Irish
